Publications

 

Selected publications from the lab from recent years

2017

Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression. Eriksson K, Svensson A, Hait AS, Schlüter K, Tunbäck P, Nordström I, Padyukov L, Liljeqvist JÅ, Mogensen TH, Paludan SR. J Immunol. 2017 Oct 15;199(8):2613-2617. doi: 10.4049/jimmunol.1700385.

Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure. Gram AM, Sun C, Landman SL, Oosenbrug T, Koppejan HJ, Kwakkenbos MJ, Hoeben RC, Paludan SR, Ressing ME. Mol Immunol. 2017 Nov;91:225-237. doi: 10.1016/j.molimm.2017.08.025. 

Live and let die: ZBP1 senses viral and cellular RNAs to trigger necroptosis. Assil S, Paludan SR. EMBO J. 2017 Sep 1; 36(17):2470-2472. doi: 10.15252/embj.201797845.

cGAS is activated by DNA in a length-dependent manner. Luecke S, Holleufer A, Christensen MH, Jønsson KL, Boni GA, Sørensen LK, Johannsen M, Jakobsen MR, Hartmann R, Paludan SR. EMBO Rep. 2017 Oct; 18(10):1707-1715. doi: 10.15252/embr.201744017.

Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections. Ogunjimi B, Zhang SY, Sørensen KB, Skipper KA, Carter-Timofte M, Kerner G, Luecke S, Prabakaran T, Cai Y, Meester J, Bartholomeus E, Bolar NA, Vandeweyer G, Claes C, Sillis Y, Lorenzo L, Fiorenza RA, Boucherit S, Dielman C, Heynderickx S, Elias G, Kurotova A, Auwera AV, Verstraete L, Lagae L, Verhelst H, Jansen A, Ramet J, Suls A, Smits E, Ceulemans B, Van Laer L, Plat Wilson G, Kreth J, Picard C, Von Bernuth H, Fluss J, Chabrier S, Abel L, Mortier G, Fribourg S, Mikkelsen JG, Casanova JL, Paludan SR, Mogensen TH. J Clin Invest. 2017 Sep 1; 127(9):3543-3556. doi: 10.1172/JCI92280.

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Jønsson KL, Laustsen A, Krapp C, Skipper KA, Thavachelvam K, Hotter D, Egedal JH, Kjolby M, Mohammadi P, Prabakaran T, Sørensen LK, Sun C, Jensen SB, Holm CK, Lebbink RJ, Johannsen M, Nyegaard M, Mikkelsen JG, Kirchhoff F, Paludan SR, Jakobsen MR. Nat Commun. 2017 Feb 10;8:14391. doi: 10.1038/ncomms14391.

 

2016

Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. / Reinert, Line S; Lopušná, Katarína; Winther, Henriette; Sun, Chenglong; Thomsen, Martin K; Nandakumar, Ramya; Mogensen, Trine H; Meyer, Morten; Vægter, Christian; Nyengaard, Jens R; Fitzgerald, Katherine A; Paludan, Søren RNature Communications, Vol. 7, 10.11.2016, p. 13348.

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection. / Thomsen, Martin K; Nandakumar, Ramya; Stadler, Daniela; Malo, Antje; Valls, Roser Marin; Wang, Fan; Reinert, Line S; Dagnaes-Hansen, Frederik; Hollensen, Anne Kruse; Mikkelsen, Jacob Giehm; Protzer, Ulrike; Paludan, Søren RHepatology, Vol. 64, No. 3, 16.06.2016, p. 746-759.

An innate antiviral pathway acting before interferons at epithelial surfaces. Iversen MB, Reinert LS, Thomsen MK, Bagdonaite I, Nandakumar R, Cheshenko N, Prabakaran T, Vakhrushev SY, Krzyzowska M, Kratholm SK, Ruiz-Perez F, Petersen SV, Goriely S, Bibby BM, Eriksson K, Ruland J, Thomsen AR, Herold BC, Wandall HH, Frische S, Holm CK, Paludan SR. Nat Immunol. 2016 Feb;17(2):150-8. doi: 10.1038/ni.3319.

Innate Antiviral Defenses Independent of Inducible IFNα/β Production. Paludan SR. Trends Immunol. 2016 Sep;37(9):588-96. doi: 10.1016/j.it.2016.06.003. Review

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses. / Holm, Christian K; Rahbek, Stine H; Gad, Hans Henrik; Bak, Rasmus O; Jakobsen, Martin R; Jiang, Zhaozaho; Hansen, Anne Louise; Jensen, Simon K; Sun, Chenglong; Thomsen, Martin K; Laustsen, Anders; Nielsen, Camilla G; Severinsen, Kasper; Xiong, Yingluo; Burdette, Dara L; Hornung, Veit; Lebbink, Robert Jan; Duch, Mogens; Fitzgerald, Katherine A; Bahrami, Shervin; Mikkelsen, Jakob Giehm; Hartmann, Rune; Paludan, Søren R. Nature Communications, Vol. 7, 2016, s. 10680

 

2015

Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis. / Mørk, N; Kofod-Olsen, E; Sørensen, K B; Bach, E; Ørntoft, T F; Østergaard, Lars Jørgen; Paludan, S R; Christiansen, M; Mogensen, Trine. Genes and Immunity, Vol. 16, Nr. 8, 12.2015, s. 552-66.

An innate antiviral pathway acting before interferons at epithelial surfaces. / Iversen, Marie B; Reinert, Line S; Thomsen, Martin K; Bagdonaite, Ieva; Nandakumar, Ramya; Cheshenko, Natalia; Prabakaran, Thaneas; Vakhrushev, Sergey Y; Krzyzowska, Malgosha; Kratholm, Sine K; Ruiz-Perez, Fernando; Petersen, Steen V; Goriely, Stanislas; Bibby, Bo Martin; Eriksson, Kristina; Ruland, Jürgen; Thomsen, Allan R; Herold, Betsy C; Wandall, Hans H; Frische, Sebastian; Holm, Christian K; Paludan, Søren R. Nature Immunology, 30.11.2015.

Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection. / Sun, Chenglong; Schattgen, Stefan A; Pisitkun, Prapaporn; Jorgensen, Joan P; Hilterbrand, Adam T; Wang, Lucas J; West, John A; Hansen, Kathrine; Horan, Kristy A; Jakobsen, Martin Roelsgaard; O'Hare, Peter; Adler, Heiko; Sun, Ren; Ploegh, Hidde L; Damania, Blossom; Upton, Jason W; Fitzgerald, Katherine A; Paludan, Søren R. Journal of Immunology, Vol. 194, Nr. 4, 15.02.2015, s. 1819-31.

Functional IRF3 deficiency in a patient with herpes simplex encephalitis. / Andersen, Line Lykke; Mørk, Nanna; Reinert, Line S; Kofod-Olsen, Emil; Narita, Ryo; Jørgensen, Sofie E; Skipper, Kristian A; Höning, Klara; Gad, Hans Henrik; Østergaard, Lars; Ørntoft, Torben F; Hornung, Veit; Paludan, Søren R; Mikkelsen, Jacob Giehm; Fujita, Takashi; Christiansen, Mette; Hartmann, Rune; Mogensen, Trine H. Journal of Experimental Medicine, Vol. 212, Nr. 9, 2015, s. 1371-9.

 

2014

TRAM is required for TLR2 endosomal signaling to type I IFN induction. / Stack, Julianne; Doyle, Sarah L; Connolly, Dympna J; Reinert, Line S; O'Keeffe, Kate M; McLoughlin, Rachel M; Paludan, Søren R; Bowie, Andrew G. Journal of Immunology, Vol. 193, Nr. 12, 15.12.2014, s. 6090-102.

Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway. / Hansen, Kathrine; Prabakaran, Thaneas; Laustsen, Anders; Jørgensen, Sofie E; Rahbæk, Stine H; Jensen, Søren B; Nielsen, Rikke; Leber, Jess H; Decker, Thomas; Horan, Kristy A; Jakobsen, Martin R; Paludan, Søren R. E M B O Journal, Vol. 33, Nr. 15, 01.08.2014, s. 1654-66.

IFI16 : At the interphase between innate DNA sensing and genome regulation. / Jakobsen, Martin Roelsgaard; Paludan, Søren R. Cytokine & Growth Factor Reviews, 21.06.2014

Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates to chronic immune activation. / Nissen, Sara K; Højen, Jesper Falkesgaard; Andersen, Karen L D; Kofod-Olsen, Emil; Berg, Randi K; Paludan, Søren R; Ostergaard, Lars; Jakobsen, Martin Roelsgaard; Tolstrup, Martin; Mogensen, Trine H. Clinical and Experimental Immunology, Vol. 177, Nr. 1, 05.03.2014, s. 295-309.

Inflammatory Cytokines Break Down Intrinsic Immunological Tolerance of Human Primary Keratinocytes to Cytosolic DNA. / Chiliveru, Srikanth; Rahbek, Stine H; Jensen, Simon K; Jørgensen, Sofie E; Nissen, Sara K; Christiansen, Stig H; Mogensen, Trine H; Jakobsen, Martin R; Iversen, Lars; Johansen, Claus; Paludan, Søren R. Journal of Immunology, 2014.

T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses : Implications for Restriction of HIV Replication. / Berg, Randi K; Rahbek, Stine Hess; Kofod-Olsen, Emil; Holm, Christian K; Melchjorsen, Jesper; Jensen, David G.; Hansen, Anne Louise; Jørgensen, Louise B.; Østergaard, Lars Jørgen; Tolstrup, Martin; Larsen, Carsten S; Paludan, Søren R; Jakobsen, Martin R; Mogensen, Trine H. PloS one, Vol. 9, Nr. 1, 2014, s. e84513. 

 

2013

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. / Jakobsen, Martin Roelsgaard; Bak, Rasmus O; Andersen, Annika; Berg, Randi K; Jensen, Søren B; Tengchuan, Jin; Laustsen, Anders; Hansen, Kathrine; Ostergaard, Lars; Fitzgerald, Katherine A; Xiao, T Sam; Mikkelsen, Jacob G; Mogensen, Trine H; Paludan, Søren R. National Academy of Sciences. Proceedings, 23.10.2013.

Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection. / Vibholm, Line; Reinert, Line S; Søgaard, Ole S; Paludan, Søren R; Østergaard, Lars Jørgen; Tolstrup, Martin; Melchjorsen, Jesper. AIDS Research and Human Retroviruses, Vol. 28, Nr. 11, 2012, s. 1404-11.

Caught in translation : innate restriction of HIV mRNA translation by a schlafen family protein. / Jakobsen, Martin Roelsgaard; Mogensen, Trine H; Paludan, Søren R. Cell Research, 2012.

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. / Holm, Christian K; Jensen, Søren B; Jakobsen, Martin Roelsgaard; Cheshenko, Natalia; Horan, Kristy A; Moeller, Hanne B; Gonzalez-Dosal, Regina; Rasmussen, Simon B; Christensen, Maria H; Yarovinsky, Timur O; Rixon, Frazer J; Herold, Betsy C; Fitzgerald, Katherine A; Paludan, Søren R. Nature Immunology, Vol. 13, Nr. 8, 2012, s. 737-43.